I'm not clear on what a hybrid connection is. Is this Microsoft explanation stating that once you set up an application to use a port and tcp endpoint that it will use the same port and tcp endpoint on another server to reach it's destination?
Within App Service, Hybrid Connections can be used to access application resources in any network that can make outbound calls to Azure over port 443. Hybrid Connections provides access from your app to a TCP endpoint and does not enable a new way to access your app. As used in App Service, each Hybrid Connection correlates to a single TCP host and port combination. This enables your apps to access resources on any OS, provided it is a TCP endpoint. The Hybrid Connections feature does not know or care what the application protocol is, or what you are accessing. It simply provides network access.